Epigenetic targeting in oral squamous cell carcinoma: mechanisms, therapies, and translational potential

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Oral squamous cell carcinoma exhibits rapid progression and poor prognosis, necessitating innovative treatment strategies.
Epigenetic alterations, including DNA methylation and histone modifications, are crucial in regulating oncogene activation and tumor suppressor genes.
Current research is exploring the potential of targeting these epigenetic mechanisms for developing novel therapies for OSCC.
Understanding these epigenetic drivers could lead to improved therapeutic options and better outcomes for OSCC patients.

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This review highlights mechanisms of epigenetic alterations in OSCC, suggesting potential therapies and translational applications.

Yang et al. (2025) studied this question.

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