Dual Functioning Ru(II)/Ir(III) Complexes for Ferroptosis and Apoptosis in Triple Negative Breast Cancer: A Proof of Concept by Glutathione Depletion

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This is a Experimental Study study.

Utpal Das; Tiasha Dasgupta; Krishna Santhoshkumar; Jayaprakash Meena; Annamalai Senthil Kumar; Rajesh Kushwaha; Rishav Das; Debasish Mondal; Kuntal Maji; Prasanta Ghosh; Samya Banerjee; Ramasamy Tamizhselvi; Rinku Chakrabarty; Priyankar Paira

doi:10.1039/d5dt01428j

January 1, 2025Dalton Transactions

Dual Functioning Ru(II)/Ir(III) Complexes for Ferroptosis and Apoptosis in Triple Negative Breast Cancer: A Proof of Concept by Glutathione Depletion

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Key Points

The study demonstrates that Ru(II)/Ir(III) complexes can induce ferroptosis and apoptosis in triple negative breast cancer cells.
Key evidence includes the observation that glutathione depletion promotes these cell death pathways in TNBC.
This assessment utilized dual-functioning Ru(II)/Ir(III) complexes to target cancer cell survival mechanisms effectively.
The findings suggest that targeting both ferroptosis and apoptosis could enhance therapeutic strategies against TNBC.

Implication

Proof of concept reveals dual-targeting by Ru(II)/Ir(III) complexes affecting ferroptosis and apoptosis in TNBC.

Abstract

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer which lacks effective targeted therapies because of negative expression of the targetable bioreceptors. Fighting with TNBC requires innovative...

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Cite This Study

Das et al. (2025) studied this question.

synapsesocial.com/papers/68e02f3cf0e39f13e7fa25ae https://doi.org/10.1039/d5dt01428j

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Dual Functioning Ru(II)/Ir(III) Complexes for Ferroptosis and Apoptosis in Triple Negative Breast Cancer: A Proof of Concept by Glutathione Depletion

Key Points

Implication

Abstract

Discussion

Cite This Study

Dual Functioning Ru(II)/Ir(III) Complexes for Ferroptosis and Apoptosis in Triple Negative Breast Cancer: A Proof of Concept by Glutathione Depletion

Key Points

Implication

Abstract

Discussion

Cite This Study

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