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October 3, 2025Open Access

Neuronal migration depends on blood flow in the adult brain

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Blood flow promotes the migration of new olfactory-bulb neurons in the adult brain, enhancing the accumulation of neurons near blood vessels.
Inhibition of blood flow reduces blood vessel-guided neuronal migration, indicating that factors in blood assist neuronal movement.
Ghrelin, a hormone increased by hunger, directly influences neuronal migration by affecting actin cytoskeleton dynamics.
Calorie restriction boosts neuronal migration while also enhancing ghrelin signaling, linking metabolism and neuronal function.

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Research reveals that blood flow enhances neuronal migration in the adult olfactory bulb, suggesting ghrelin's role in this process.

Ogino et al. (2025) studied this question.

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