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October 3, 2025Open Access

A co-evolutionary perspective on humans and Mycobacterium tuberculosis in the era of systems biology

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Authors

MRMichaela T. ReichmannLTLiku B. TezeraLDLaura Denney

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Overview

This analysis uncovers the complex host-pathogen interaction in tuberculosis, suggesting systems biology can transform our understanding of immune responses.

Key Points

  • Tuberculosis remains the deadliest infectious disease, underscoring the urgency for effective control measures.
  • The complex host-pathogen interaction hinges on the long-standing co-evolution between humans and Mycobacterium tuberculosis.
  • Emerging methodologies like spatial transcriptomics offer unprecedented insights into immunological details.
  • Relying on a single unifying mechanism may hinder progress; a multifaceted approach is essential for breakthroughs.

Cite This Study

Reichmann et al. (2025) studied this question.

synapsesocial.com/papers/68e02f3cf0e39f13e7fa271bhttps://doi.org/10.7554/elife.108175.1
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