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This is a Experimental Study study.

October 3, 2025Open Access

Retinal Organoid Single-Cell Transcriptomics Reveals Effects of PRPF31 Mutation on Early Müller Glial Activation and Progressive Photoreceptor Degeneration

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Single-cell transcriptomics reveals early Müller glial activation and retinal stress in prpf31-associated retinitis pigmentosa.

PRPF31 mutation leads to early Müller glial activation and photoreceptor degeneration in retinal organoids.
Single-cell RNA sequencing shows dysregulated pathways involved in phototransduction and oxidative stress.
Retinal organoids effectively model key features of retinitis pigmentosa, highlighting treatment targets for RP11.
Findings suggest early molecular changes contribute to progressive photoreceptor loss in retinitis pigmentosa.

Bellapianta et al. (2025) studied this question.

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