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October 3, 2025ChemistrySelectOpen Access

Natural Products from Mexican Medicinal Plants as Promising Trypanocidal Drugs

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Authors

KRKarla Daniela Rodríguez‐HernándezUniversidad Nacional Autónoma de MéxicoEJElia Guadalupe Jaimes‐CastelánUniversidad Nacional Autónoma de MéxicoRRRicardo Reyes‐ChilpaUniversidad Nacional Autónoma de México

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Overview

This review assesses anti-T. cruzi compounds in medicinal plants, suggesting new trypanocidal drugs to combat Chagas disease.

Key Points

  • Secondary metabolites from Mexican plants show potential as new trypanocidal drugs against Chagas disease.
  • Current treatments like nifurtimox and benznidazole have low efficacy and can cause toxicity, highlighting the need for better options.
  • The review focuses on literature from 2012 to 2024, identifying compounds with activity against stages of Trypanosoma cruzi.
  • In vivo trials and pharmacokinetic studies are essential for advancing these natural products into effective therapies.

Cite This Study

Rodríguez‐Hernández et al. (2025) studied this question.

synapsesocial.com/papers/68e02f40f0e39f13e7fa2a44https://doi.org/10.1002/slct.202504830
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Also Consider

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  1. 1Chagas Disease2023 · 92 citations
  2. 2Introducing the NUATEI Consortium: A Mexican Research Program for the Identification of Natural and Synthetic Antimicrobial Compounds for Prevalent Infectious Diseases2024 · 2 citations
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  4. 4Trypanocidal Constituents in Plants 5. Evaluation of Some Mexican Plants for Their Trypanocidal Activity and Active Constituents in the Seeds of Persea americana2005 · 57 citations
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