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This is a Experimental Study study.

October 3, 2025Open Access

Oxidative Rearrangement of Indoles Enabled by Promiscuous Cryptic Halogenation with Vanadium-Dependent Haloperoxidases

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The catalytic system transforms indoles into 2-oxindoles with minimal waste, enhancing sustainability in synthetic processes.
Utilizing vanadium-dependent haloperoxidases and halide salts, the method achieves effective enzyme-catalyzed reactions.
This approach enables multi-enzymatic synthesis and late-stage modifications of biologically relevant molecules.
The protocol facilitates gram-scale synthesis of compounds like coerulescine, broadening its practical application.

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Biocatalytic platform optimizes the oxidative rearrangement of indoles to 2-oxindoles, suggesting a greener alternative.

Lee et al. (2025) studied this question.

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