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October 3, 2025Pakistan Postgraduate Medical JournalOpen Access

Diagnostic Accuracy of Fnac and Core Needle Biopsy in Palpable Breast Lumps: A Meta-Analysis of Comparative Studies

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Authors

AAAslam javed AslamHHHuma Aslam HumaMHMuhammad HassanAnhui Medical University

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Implication

Meta-analysis evaluates diagnostic accuracy, sensitivity, and specificity of FNAC and CNB in palpable breast lumps, implying CNB's superior performance.

Key Points

  • CNB showed a higher pooled sensitivity range of 82.86% to 100%, indicating better diagnostic reliability than FNAC.
  • The specificities of FNAC ranged from 48% to 100%, while CNB demonstrated more consistent specificity of 86% to 100%.
  • Diagnostic accuracy for FNAC varied between 71.4% to 96.6%, whereas CNB had more consistent accuracy from 82.8% to 100%.
  • False negatives were notably higher in FNAC, especially in inflammatory breast pathologies, reinforcing CNB's greater reliability.

Cite This Study

Aslam et al. (2025) studied this question.

synapsesocial.com/papers/68e02f46f0e39f13e7fa2ef0https://doi.org/10.51642/ppmj.v36i03.772
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Fine-Needle Aspiration Cytology in the Evaluation of Breast Lumps2024 · 4 citations
  2. 2Comparative analysis of sensitivity and specificity between fine needle aspiration and core needle biopsy in breast cancer diagnosis: Meta-analysis2024
  3. 3Preoperative diagnostic accuracy of FNAC in the diagnosis of palpable breast lesions2011
  4. 4Utility of the United Kingdom National Health Services Breast Screening Program Diagnostic Protocol in Fine-needle Aspiration Cytology with Cell Block Preparation in Cases of Palpable Breast Lumps: A Reliable, Fast, and Accurate Diagnostic Method for the Assessment of Breast Lumps with Histopathologic Correlation2024
  5. 5"Role Of Fine Needle Aspiration Cytology In Various Breast Diseases"2025