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October 3, 2025

Impaired IL-10 Receptor Signaling Leads to Inflammation Induced Exhaustion in Hematopoietic Stem Cells

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Authors

WWWilliam Lucas P WadleyUniversity of California, IrvineHHHelen HuangImperial College LondonHLHew Yeng LaiUniversity of California, Irvine

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Overview

Research reveals IL-10R signaling regulates inflammation-induced exhaustion in hematopoietic stem cells, implying potential therapeutic strategies.

Key Points

  • Impaired IL-10R signaling is critical for maintaining hematopoietic stem cell (HSC) quiescence, especially after inflammation.
  • IL-10R blockade leads to increased cycling of HSCs and accelerates aging symptoms, including functional defects.
  • Jak2V617F mutant HSCs show resistance to aging effects caused by IL-10R blockade, promoting clonal expansion.
  • Findings suggest modulating IL-10R signaling could help preserve HSCs and manage clonal hematopoiesis.

Cite This Study

Wadley et al. (2025) studied this question.

synapsesocial.com/papers/68e034f7f0e39f13e7fa30a5https://doi.org/10.1101/2025.09.30.679613
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Disruption of IL-10 receptor signaling promotes hematopoietic stem cell exhaustion and clonal expansion of JAK2V617F mutant cells during inflammatory stress2025 · 1 citations
  2. 2Rejuvenating the Aged Hematopoietic System: IL-4 Signaling Restores Lymphopoiesis and Systemic Function 23027882026
  3. 3Maintenance of haematopoietic stem cells by JAK inhibition and increased tyrosine-unphosphorylated STAT52024 · 1 citations
  4. 4Chronic Inflammation Induces a Molecular and Functional State Divergent from Physiological Aging in Hematopoietic Stem Cells 23280492026
  5. 5Loss of Foxo3a—IL-10 antagonism promotes terminal myelopoiesis via Dgat2-mediated upregulation of lipid droplet accumulation 22539072026