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July 30, 2026The Journal of Immunology

Chronic Inflammation Induces a Molecular and Functional State Divergent from Physiological Aging in Hematopoietic Stem Cells 2328049

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Authors

JYJingfei YaoYWYuting WangYZYi Zhang

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Overview

Randomized trial shows that chronic inflammation affects hematopoietic stem cells differently than aging, suggesting unique mechanisms exist.

Key Points

  • This research investigates whether chronic inflammation mimics physiological aging in hematopoietic stem cells.
  • Utilized the DARLIN mouse model for high-resolution lineage tracing.
  • Administered LPS or Poly(I:C) over 2 months to induce chronic inflammation; followed by a 2-month break.
  • Employed multi-omics analysis combining bulk RNA-seq, ATAC-seq, and scRNA-seq to profile HSCs.
  • Inflammation-treated HSCs showed reduced self-renewal in transplantation, with sustainable multilineage output.
  • Chronic inflammation led to increased chromatin accessibility and expansion of distinct HSC subpopulations, contrasting typical aging patterns.
  • In aged mice, chronic inflammation re-activated quiescent HSCs, encouraging cell cycle entry instead of worsening aging signatures.

Cite This Study

Yao et al. (2026) studied this question.

synapsesocial.com/papers/6a6af51160e2b924d3ea0aechttps://doi.org/10.1093/jimmun/vkag141.1762
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Developmental and epigenetic remodeling of inflammation in the aging human innate immune system 22389392026
  2. 2Human haematopoietic stem cells remember inflammatory stress2026 · 4 citations
  3. 3An inflammatory and quiescent HSC subpopulation expands with age in humans2026 · 2 citations
  4. 4The blood remembers: HSC-iM and the cancer continuum2026
  5. 5An Inflammatory and Quiescent HSC Subpopulation Expands with Age in Humans2025 · 1 citations