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This research aims to characterize molecular changes in hematopoietic stem cells (HSCs) with aging.

January 18, 2026Genome biologyOpen Access

An inflammatory and quiescent HSC subpopulation expands with age in humans

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This research aims to characterize molecular changes in hematopoietic stem cells (HSCs) with aging.
Integrated seven single-cell datasets to create a consensus gene expression map of HSCs.
Analyzed gene expression patterns to identify heterogeneity within the HSC population.
Examined activation of inflammatory pathways linked to HSC aging.
Identified a distinct inflammatory HSC subpopulation that expands with age.
Revealed a single gene expression program associated with both inflammatory activation and quiescence.
Established a connection between inflammatory pathways (TNF/NFκB, AP-1) and HSC aging.

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Analysis reveals inflammatory and quiescent HSC subpopulation changes with age, suggesting targets for interventions.

Safina et al. (2026) studied this question.

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