Supplementary Methods from PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer

Q: What type of study is this?

This is a Quantitative Study study.

Kentaro Umemura; Yoshimitsu Akiyama; Shu Shimada; Megumi Hatano; A. Kono; Koya Yasukawa; Atsushi Kamachi; Yosuke Igarashi; Shu Tsukihara; Yoshiaki Tanji; Koichiro Morimoto; Atsushi Nara; Masahiro Yamane; Keiichi Akahoshi; Hiroaki Ono; Akira Shimizu; Yuji Soejima; Minoru Tanabe; Daisuke Ban; Shinji Tanaka

doi:10.1158/1541-7786.30264217

Key Points

Histone citrullination was found to significantly enhance cell proliferation in pancreatic cancer, contributing to tumor growth.
Key evidence shows that the altered microenvironment created by histone citrullination promotes tumor progression.
Assessment involved various molecular and cellular assays including qRT-PCR and cytokine array analysis to uncover these associations.
These findings highlight the complex interplay between histone modifications and the tumor microenvironment in cancer development.

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Implication

Molecular analysis reveals histone citrullination drives tumor progression and alters the microenvironment in pancreatic cancer.

Abstract

Supplementary Procedures for molecular and cellular assays used in the study, including qRT-PCR, Western blotting, cell proliferation, colony formation, immunofluorescence staining, and cytokine array analysis.

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Cite This Study

Umemura et al. (2025) studied this question.

synapsesocial.com/papers/68e034f7f0e39f13e7fa32cc https://doi.org/10.1158/1541-7786.30264217

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