What type of study is this?

This is a Cohort Study study (also classified as: Quantitative Study).

October 3, 2025Open Access

DNA Methylation Profiling in Childhood-Onset Lupus Reveals Distinct Epigenetic Clusters and Suggests Epigenetic Drivers of Disease Activity

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Authors

DCDesiré Casares‐Marfil GKGülşah Kavrul Kayaalp VGVafa Guliyeva

Discussion

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Overview

Analysis reveals distinct epigenetic clusters and hypomethylation linked to disease activity in childhood-onset SLE patients, suggesting potential diagnostic applications.

Key Points

Distinct dna methylation patterns correlate with disease activity in childhood-onset sle, highlighting potential diagnostic avenues.
Significant hypomethylation was observed in interferon-regulated genes, with higher prevalence in patient groups with increased symptom severity.
K-means clustering identified three unique epigenetic subgroups that reflect underlying biological processes associated with cSLE.
Sex-based differences were noted, with immune-related hypomethylation particularly evident in male patients, emphasizing the need for personalized approaches.

Cite This Study

Casares‐Marfil et al. (2025) studied this question.

synapsesocial.com/papers/68e034fdf0e39f13e7fa3510 https://doi.org/10.1101/2025.09.30.25337006

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October 3, 2025Open Access

DNA Methylation Profiling in Childhood-Onset Lupus Reveals Distinct Epigenetic Clusters and Suggests Epigenetic Drivers of Disease Activity

View Full Paper

Ask AI

Bookmark

Authors

DCDesiré Casares‐Marfil GKGülşah Kavrul Kayaalp VGVafa Guliyeva

Discussion

Member takes

Overview

Analysis reveals distinct epigenetic clusters and hypomethylation linked to disease activity in childhood-onset SLE patients, suggesting potential diagnostic applications.

Key Points

Distinct dna methylation patterns correlate with disease activity in childhood-onset sle, highlighting potential diagnostic avenues.
Significant hypomethylation was observed in interferon-regulated genes, with higher prevalence in patient groups with increased symptom severity.
K-means clustering identified three unique epigenetic subgroups that reflect underlying biological processes associated with cSLE.
Sex-based differences were noted, with immune-related hypomethylation particularly evident in male patients, emphasizing the need for personalized approaches.

Cite This Study

Casares‐Marfil et al. (2025) studied this question.

synapsesocial.com/papers/68e034fdf0e39f13e7fa3510 https://doi.org/10.1101/2025.09.30.25337006

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