Prospective international multicentre study shows high sensitivity for detecting pemphigoid autoantibodies, suggesting underdiagnosis.
This study evaluated a Biochip™-based immunofluorescence assay for improved diagnosis of dermal-binding pemphigoid diseases by detecting autoantibodies against laminin β4, type VII collagen, and laminin 332. Results showed high sensitivity, with anti-p200 pemphigoid (laminin β4 reactivity) being more frequent than epidermolysis bullosa acquisita, suggesting underdiagnosis in clinical practice. The Biochip™ mosaic offers a valuable tool for parallel detection of key autoantibodies, potentially enhancing diagnostic accuracy and patient management.
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Patzelt et al. (2025) studied this question.
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