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September 10, 2025AntibodiesOpen Access

Antibodies to Laminin β4 in Pemphigoid Diseases: Clinical–Laboratory Experience of a Single Central European Reference Centre

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Authors

MSMaciej SpałekMJMagdalena JałowskaNWNatalia Welc

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Overview

Clinical analysis identifies anti-laminin β4 antibodies in pemphigoid patients, suggesting better diagnostic strategies.

Key Points

  • Six of ten patients with a positive direct immunofluorescence test showed presence of anti-laminin β4 antibodies.
  • In contrast, no positive anti-laminin β4 antibodies were found in patients with concurrent BP180 and/or BP230 positive results.
  • Testing for anti-laminin β4 antibodies should be considered in cases with positive direct immunofluorescence and negative ELISAs.
  • This study emphasizes the need for improved diagnostic processes in atypical cases of pemphigoid diseases.

Cite This Study

Spałek et al. (2025) studied this question.

synapsesocial.com/papers/68c1b34d54b1d3bfb60e9b43https://doi.org/10.3390/antib14030066
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