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August 20, 2026British Journal of Dermatology

Anti-p200 pemphigoid: A multi-institutional North American case series of 47 patients with clinical, serologic, and histopathologic data

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Authors

SAShruti AgrawalLWLindsey J WanbergMCMichael J Camilleri

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Overview

Case series characterizes clinical, serologic, and histopathologic profiles in patients with anti-p200 pemphigoid, highlighting key diagnostic features of this autoimmune blistering disease.

Key Points

  • Characterize the clinical, serologic, and histopathologic features in a cohort of patients with anti-p200 pemphigoid.
  • Multi-institutional case series of N=47 patients identified at Mayo Clinic (Rochester, MN, USA) and Beutner Laboratories (Buffalo, NY, USA).
  • Serologic detection of anti-p200 laminin beta 4 autoantibodies performed using IgG or IgG4 modified indirect immunofluorescence on HEK293 cells transfected with recombinant laminin beta.
  • Identified 47 patients with positive serology confirming anti-p200 laminin beta 4 autoantibodies.
  • Characterized circulating IgG and IgG4 autoantibody reactivity to recombinant laminin beta targets across the multi-center cohort.

Cite This Study

Agrawal et al. (2026) studied this question.

synapsesocial.com/papers/6a86b6208a91293e6a1cdc15https://doi.org/10.1093/bjd/ljag339
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antibodies to Laminin β4 in Pemphigoid Diseases: Clinical–Laboratory Experience of a Single Central European Reference Centre2025
  2. 2Retrospective Analysis of Clinical and Immunoserological Features in 86 Cases of Anti‐p200 Pemphigoid2025
  3. 3Clinical and immunoserological characteristics of anti‐p200 pemphigoid: Comparisons of patients with epitope spreading and non‐epitope spreading2024 · 1 citations
  4. 4Anti‐ <scp>p200</scp> Pemphigoid in an Infant Clinically Mimicking Linear <scp>IgA</scp> Disease2026
  5. 5Standardized Indirect Immunofluorescence-Based Detection of Dermal-Binding Autoantibodies in Pemphigoid Diseases: a prospective international multicentre study2025