Literature review correlates sCD14 levels with rheumatoid arthritis severity, suggesting cardiovascular risks.
Objective. To identify a possible correlation between the concentration of sCD14 and the severity of rheumatoid arthritis, to determine its role in the pathological process. Material and methods. The literature review includes an analysis of scientific papers from the databases PubMed, MEDLINE, Embase, eLibrary, CyberLeninka and GoogleScholars. Conclusion. CD14 performs several important and potentially different biological functions, including endotoxin binding, mediation of cellular apoptosis, as well as regulation of lymphocyte activation and function, and acts as an acute phase protein. sCD14 may serve as a potential "link" explaining the increased risk of cardiovascular disease observed in patients with rheumatoid arthritis.
No takes yet. Share an insight, caveat, or question.
Kaliberdenko et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: