Risk factors for the development of resistant arterial hypertension

Resistant arterial hypertension (AH) continues to be a serious medical and social problem throughout the world. The aim of the study was to identify risk factors for the development of resistant AH. A total of 50 patients with truly resistant AH (main group) and 45 patients with controlled AH (comparison group) were examined. We studied β-ARME, NO, ET-1, hs-CRP, IL-6, IL-17, and TNF-α levels in blood plasma. Statistically significant differences were found between the resistant hypertension group and the controlled hypertension group in terms of β-ARME (p=0.002), NO (p=0.028), ET-1 (p=0.006), TNF-α (p<0.001), and IL-6 (p=0.002). The following predictors of resistant hypertension development were identified: β-ARME ≥52.3 conventional units, SOD blood content ≤9.7 U/ml, NO ≤16.7 mmol/l, ET-1≥11.5 pg/ml, TNF-α≥4.2 pg/ml. Determining the risk of developing resistant hypertension is important and necessary for developing effective therapeutic strategies, ensuring blood pressure control and improving the prognosis in this category of patients.