Optimization of the of green synthetized MgO nanoparticles by Spirogyra varians and determine its anticancer activity against breast cancer

Algae samples were taken from 2nd February to 21st April 2023. Various parameters including temperature, acidity, turbidity, electricity, and the presence of nutrients such as nitrogen (NO3) and phosphorus (PO3) were recorded. Following the identification of Spirogyra varians, an algal extraction was conducted using methanol as the solvent. The algal extract was utilized to synthesize Mgo nanoparticles (MgONPs), 0.05 M concentrations of Mg(NO3)2H2O with a reaction degree equal to 80º at 6 pH were used as conditions of the green synthesized. The green-generated MgONPs were characterized using UV-Vis, FESEM, EDS, and XRD techniques. The anticancer efficacy against MCF-7 breast cancer cells and its correlation with Reactive Oxygen Species (ROS) were assessed. The findings demonstrated significant efficacy and impact of the produced magnesium oxide nanoparticles (MgONPs) against MCF-7 breast cancer cells. Additionally, a clear correlation was seen between MgONPs and reactive oxygen species (ROS) in the cancer cell line.