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October 3, 2025Asian Journal of Social and Humanities

Administration of Corosolic Acid Decreased MDA, HMG-CoA, Through Increased Leptin and GLP-1 Levels in Obese Male Rats

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Authors

FMFransiska MochtarUdayana UniversityWPWimpie PangkahilaUdayana UniversityIDI Gusti Ayu Sri Mahendra DewiUdayana University

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Implication

Experimental analysis showed corosolic acid reduces MDA and HMG-CoA, while increasing leptin and GLP-1 in obese rats, suggesting potential therapeutic effects.

Key Points

  • Corosolic acid treatment significantly reduced MDA and HMG-CoA levels in obese rats.
  • Leptin and GLP-1 levels increased significantly after treatment with corosolic acid at p<0.0001.
  • The study used the ELISA method to assess the biochemical changes in serum and plasma.
  • Corosolic acid shows promise as an alternative obesity therapy, highlighting its antioxidant properties.

Cite This Study

Mochtar et al. (2023) studied this question.

synapsesocial.com/papers/68e03509f0e39f13e7fa4042https://doi.org/10.59888/ajosh.v2i03.204
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Also Consider

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  1. 1UPLC-Q-TOF/MS-Based Metabolomics and 16S rRNA Profiling Reveal that Corosolic Acid Ameliorates High-Fat Diet-Induced MASLD by Modulating the Gut-Liver Axis to Inhibit the cGAS-STING Pathway2026 · 2 citations
  2. 2Corosolic Acid Attenuates Hepatic Lipid Accumulation and Inflammatory Response via AMPK/SREBPs and NF-κB/MAPK Signaling Pathways2020 · 31 citations
  3. 3Corosolic acid ameliorates non‐alcoholic steatohepatitis induced by high‐fat diet and carbon tetrachloride by regulating TGF ‐β1/Smad2, NF‐κB, and AMPK signaling pathways2021 · 65 citations
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  5. 5A Natural Polyphenol, Chlorogenic Acid, Attenuates Obesity-Related Metabolic Disorders in Male Rats via miR-146a-IRAK1-TRAF6 and NRF2-Mediated Antioxidant Pathways2025 · 17 citations