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October 3, 2025Clinical ChemistryOpen Access

B-318 Performance of a LC-MS/MS assay for the multiplexed detection of cannabinoid metabolites

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Authors

SSSpencer SeelyUniversity of MontanaMGMaofa GeSecond Military Medical UniversityRFRobert D. FitzgeraldUniversity of California, San Diego

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Implication

Developed LC-MS/MS assay quantifies cannabinoids and their metabolites, highlighting therapeutic potential in clinical trials.

Key Points

  • The validation of a multiplexed LC-MS/MS assay provides reliable detection of cannabinoids in plasma.
  • Assay showed an analytical measurement range from 0.5 ng/mL to 3000 ng/mL for cannabinoids, demonstrating high accuracy.
  • The study involved 100 clinical specimens, ensuring robust method validation and reproducibility.
  • Results indicate low variability in measurements, with mean coefficients of variation for cannabinoids around 4.9% to 6.8%.

Cite This Study

Seely et al. (2025) studied this question.

synapsesocial.com/papers/68e040e9a99c246f578b3090https://doi.org/10.1093/clinchem/hvaf086.705
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