Phylogeny-directed discovery and mutagenesis of a tricyclic gersemiane synthase

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This is a Quantitative Study study.

Xiaochen Chen; Chen Bao; XU Bao-fu

doi:10.1039/d5ob01208b

January 1, 2025Organic & Biomolecular ChemistryOpen Access

Phylogeny-directed discovery and mutagenesis of a tricyclic gersemiane synthase

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Key Points

This research identifies a mechanism for generating gersemiane terpenoids through specific mutagenesis techniques.
The study demonstrates that using phylogenetic analysis can guide the development of synthases to produce new compounds.
Current knowledge gaps regarding classical terpene synthesis methods are addressed, with implications for future research.
The focus on tricyclic structures opens new avenues for exploring biodiversified terpenoid compounds.

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Implication

Analysis reveals the role of phylogeny in discovering gersemiane synthase, suggesting new pathways for terpenoid synthesis.

Abstract

Eunicellane diterpenoids, characterized by a 6,10-bicyclic core, are prone to undergo further cyclization into gersemiane diterpenoids via acid- or epoxidation-mediated protonation. However, it remains unclear whether classical type I terpene...

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68e040f3a99c246f578b35b8 https://doi.org/10.1039/d5ob01208b

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Phylogeny-directed discovery and mutagenesis of a tricyclic gersemiane synthase

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Phylogeny-directed discovery and mutagenesis of a tricyclic gersemiane synthase

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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