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This is a Literature Review study.

Genetic Diversity of Sickle Cell Disease in Nigeria: Implication for Emerging Gene Therapy and Health Equity

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This review uncovers the genetic diversity of sickle cell disease, indicating implications for gene therapy and health equity in Nigeria.

Nigeria accounts for nearly 50% of global sickle cell disease births, emphasizing the need for targeted therapies.
The heterogeneous genetic landscape of SCD is driven by diverse β-globin haplotypes and varying allele frequencies.
Emerging gene therapy approaches like CRISPR-Cas9 and hydroxyurea are pivotal for improved therapeutic response.
Barriers to equitable access highlight the need for policy priorities and capacity-building strategies in Nigeria.

Obaze et al. (2025) studied this question.

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