Procalcitonin-Guided Antibiotic Therapy in Adult Sepsis: A Biochemical Perspective from a Retrospective Cohort Study

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Discussion

Retrospective cohort study shows PCT-guided therapy improves clinical outcomes in sepsis patients, suggesting effective management.

PCT-guided antibiotic therapy shows greater reductions in bacterial infection markers compared to standard therapy.
The study found a complete response rate of 17.54% in the PCT-guided group versus 3.77% in the standard group.
Patients in the PCT-guided group experienced shorter treatment durations and fewer secondary infections.
No significant differences were noted in 28-day mortality between the two groups.

Zhang et al. (2025) studied this question.

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