Supplementary Figure S2 from Spatial Tumor Immune Microenvironment as a Prognostic and Predictive Biomarker in Anti–EGFR-Based Maintenance for RAS wt Metastatic CRC—The PanaMa (AIO KRK0212) Trial

Key Points

Overall response rates significantly impact treatment outcomes, especially in patients with metastatic CRC.
The study emphasizes the relationship between immune microenvironment and treatment efficacy in anti-EGFR therapy.
Metastatic CRC patients with RAS wild type benefit more from anti-EGFR-based maintenance strategies.
Prognostic biomarkers, such as immune microenvironment indicators, could guide personalized treatment approaches.

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Risk analysis shows overall response rates in metastatic CRC patients, suggesting immune microenvironment's prognostic value.

Risk analysis of Overall Response Rates in the Induction set.

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Ballhausen et al. (2025) studied this question.

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