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October 3, 2025Open Access

Supplemental Figure 1 from Beyond the Promoter: Total MGMT Gene Methylation Modulates Response to DNA-Alkylating Agents in Glioma

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Authors

NBNicole BricenoNational Cancer InstituteJJJinkyu JungNational Institutes of HealthALAmin LiBrigham and Women's Hospital

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Implication

Observational analysis shows changes in MGMT gene methylation in glioma, suggesting it affects treatment response to DNA-alkylating agents.

Key Points

  • Increased MGMT gene methylation reduces glioma cell resistance to DNA-alkylating agents, enhancing treatment effectiveness.
  • Analysis of expression data from the NCI-60 reveals significant correlations between MGMT methylation levels and cell line responses.
  • Observational analysis of glioma cell lines shows differential effects of DNA-alkylating agents based on MGMT gene status.
  • These findings highlight the potential for using MGMT methylation as a predictive biomarker for treatment outcomes in glioma.

Cite This Study

Briceno et al. (2025) studied this question.

synapsesocial.com/papers/68e040f7a99c246f578b3d6dhttps://doi.org/10.1158/1535-7163.30255703
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supplemental Table 1 from Beyond the Promoter: Total <i>MGMT</i> Gene Methylation Modulates Response to DNA-Alkylating Agents in Glioma2025
  2. 2Supplemental Figure 2 from Beyond the Promoter: Total <i>MGMT</i> Gene Methylation Modulates Response to DNA-Alkylating Agents in Glioma2025
  3. 3Data from Beyond the Promoter: Total <i>MGMT</i> Gene Methylation Modulates Response to DNA-Alkylating Agents in Glioma2025
  4. 4Correlation of O<sup>6</sup>-Methylguanine Methyltransferase (MGMT) Promoter Methylation With Clinical Outcomes in Glioblastoma and Clinical Strategies to Modulate MGMT Activity2008 · 808 citations
  5. 5DNA methylation of silencer-annotated regions at the MGMT locus in the context of promoter and enhancer methylation in glioblastoma and melanoma brain metastases2026