October 3, 2025Acta PhysiologicaOpen Access

Transduction Mechanisms for Cold Temperature in Mouse Trigeminal and Vagal Ganglion Neurons Innervating Different Peripheral Organs

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Cold sensitivity is critically influenced by TRPA1 in visceral neurons, indicating its role in cold transduction.
Inhibition of TRPM8 has minimal effect on vagal ganglion cold sensitivity, while TRPA1 knockout drastically reduces cold responses.
Cold-sensitive neurons differ between trigeminal and vagal ganglia, with distinct molecular profiles affecting responses to cold.
Both ganglia show a subset of cold-sensitive neurons with an excitability mechanism independent of TRPA1 and TRPM8.

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Observational analysis reveals TRPA1's key role in cold sensitivity among trigeminal and vagal neurons, highlighting mechanistic differences.

Gers‐Barlag et al. (2025) studied this question.

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Observational analysis reveals TRPA1's key role in cold sensitivity among trigeminal and vagal neurons, highlighting mechanistic differences.