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October 5, 2025Open Access

METTL3 Uncouples Chromatin Accessibility from Transcription during Retinal Development

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Authors

JXJing XuJiangsu UniversityYHYuanhao HuangNashville Oncology AssociatesZHZhaowei HanUniversity of Michigan

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Overview

Experimental analysis uncovers METTL3's influence on chromatin accessibility and transcription in retinal progenitor cells, indicating a complex regulatory mechanism.

Key Points

  • Loss of METTL3 affects retinal progenitor cell differentiation, disrupting Rx+ retinal anlage formation in vitro.
  • m6A at the Six3 3'UTR was found to control its stability, despite changes in chromatin accessibility.
  • Using a degron-based strategy, changes in the METTL3-Ythdf1 axis were linked to rapid shifts in regulation.
  • Multi-omics analysis highlights the essential role of METTL3 in retinal development as a distinct epitranscriptomic layer.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68e22da774308421369af009https://doi.org/10.1101/2025.10.02.680012
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1METTL3 uncouples chromatin accessibility from transcription during retinal development2025 · 1 citations
  2. 2Essential role of METTL3 in mitochondrial function and epigenetic regulation during preimplantation development in mice2026
  3. 3Stage-specific requirement for METTL3-dependent m6A epitranscriptomic regulation during myogenesis2025
  4. 4The role of METTL3 in transposable elements regulation and 2C-like program induction in mouse embryonic stem cell2025
  5. 5Mettl3 promotes reprogramming and axonogenesis of induced retinal ganglion cells2026