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October 5, 2025Open Access

Neural activity profiles reveal overlapping, intermingled subpopulations spanning area borders in mouse sensorimotor cortex

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Neurons exhibited distinct response profiles across the cortical areas, with overlaps intermingling different subpopulations.
Shifts in neuronal response characteristics at anatomical borders indicated varying tuning in motor and somatosensory areas.
Two-photon calcium imaging captured activity across >39,000 neurons, enabling detailed analysis of neural patterns.
Findings suggest that behaviorally-relevant neural activity spans multiple cortical areas with complex spatial relationships.

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Calcium imaging characterizes neuronal responses in sensorimotor areas, revealing spatially-overlapping subpopulations.

Salimian et al. (2025) studied this question.

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