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October 5, 2025Endocrine OncologyOpen Access

Bilateral and recurrent adrenocortical carcinoma in MEN1 – a case report and review of the literature

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Authors

SHSophie HowarthJMJames MacFarlaneAPAugust Palma

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Overview

Case report highlights challenges in diagnosing adrenocortical carcinoma in MEN1, suggesting molecular imaging may aid detection.

Key Points

  • Bilateral adrenocortical carcinoma was confirmed in a 76-year-old woman with MEN1, highlighting diagnostic challenges.
  • Genetic diagnosis of MEN1 plays a crucial role in understanding the increased risk of adrenocortical carcinoma and related lesions.
  • Molecular imaging techniques, including PET-CT, helped differentiate between benign and malignant adrenal lesions.
  • Case reports and cohort studies indicate a complex relationship between MEN1 and adrenocortical carcinoma, warranting further research.

Cite This Study

Howarth et al. (2025) studied this question.

synapsesocial.com/papers/68e24e59d6d66a53c2472fb6https://doi.org/10.1530/eo-25-0067
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  1. 1Extra-adrenal adrenocortical cancer associated with multiple endocrine neoplasia type 12024 · 2 citations
  2. 2In-depth Genetic and Molecular Characterization of Unilateral Coexisting Adrenal Cortical Adenoma and Carcinoma in the Context of MEN1 Syndrome2026
  3. 3A Rare Presentation of multiple endocrine neoplasia with Concurrent Aldosterone-Producing Adrenal Adenoma: a case report2024
  4. 4Primary adrenocortical carcinoma: a case report2023
  5. 5Incidental Detection of Synchronous Medullary Thyroid Carcinoma, Pheochromocytoma and Parathyroid Adenoma Leading to Diagnosis of Multiple Endocrine Neoplasia Type 2A2024