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October 5, 2025Developmental Medicine & Child NeurologyOpen Access

Three‐year outcomes of repeated botulinum neurotoxin A injections to the lower extremities in young children with spastic cerebral palsy in GMFCS levels I to III

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Authors

DFDarcy FehlingsEBEmma BohnLSLauren Switzer

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Overview

Prospective cohort study evaluated repeated botulinum neurotoxin A injections and gross motor function in children, indicating minimal effectiveness.

Key Points

  • Repeated BoNT-A injections did not improve gross motor function in young children with spastic CP over three years.
  • Outcomes indicated no significant differences in mean GMFM-66 scores between groups, with p = 0.256.
  • A cohort study compared 124 participants across GMFCS levels I to III, assessing outcomes annually.
  • Findings suggest ongoing uncertainty regarding the efficacy of BoNT-A in improving motor skills in this population.

Cite This Study

Fehlings et al. (2025) studied this question.

synapsesocial.com/papers/68e24e59d6d66a53c2472ffbhttps://doi.org/10.1111/dmcn.70031
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Botulinum Toxin Type A: Efficacy in the management of Lower Limb Spasticity in Children with Genetic Disorders2024
  2. 2Long-term functional decline following upper limb botulinum toxin injections in children with unilateral cerebral palsy: A preliminary retrospective 5-year follow-up case-control study2026
  3. 3Effectiveness and safety of abobotulinumtoxinA in pediatric lower limb spasticity: A phase IV , prospective, observational, multicenter study2025 · 1 citations
  4. 4Effect of Botulinum Toxin Type-A on Improvement of Muscle Function of Lower Limb in Children with Spastic Cerebral Palsy2024
  5. 5Longer‐term imaging of muscle quality after routine BoNT ‐A care in cerebral palsy: Beyond muscle volume2026