Enhancing 3-acetyl-11-keto-β-boswellic acid skin permeation via nanostructured lipid carriers: integrating quality by design principles for risk estimation and optimization
Nanostructured lipid carriers improved skin permeation of AKBA by 1.34-fold, suggesting quality by design approaches for better risk management.
Key Points
AKBA-loaded nanostructured lipid carriers enhanced skin permeation significantly, resulting in a 1.34-fold increase compared to plain gel.
The formulation offered sustained release of AKBA for up to 56 hours, highlighting its potential for effective long-term therapy.
Integrating quality by design principles facilitated risk estimation, ensuring more robust development and optimization of the liposomal formulation.
This innovative approach presents a scalable strategy for treating inflammatory skin disorders, contributing to advancements in dermatological therapies.