The association of family history with the risk of lung cancer: a pooled analysis of case-control studies

The risk of lung carcinoma is influenced by genetic predisposition and other risk factors. This study aimed to explore the association between a family history of any type of cancer and the risk of lung carcinoma through a pooled analysis of case-control studies. A systematic literature search was performed across Google Scholar, PubMed, and Science Direct up to January 31, 2024. Eight observational case-control studies met the inclusion criteria, which required multivariate logistic regression analysis and a focus on familial cancer history. Using Review Manager software, pooled estimates and 95% confidence intervals were calculated. Out of 603 identified studies, eight were included. The meta-analysis found that individuals with a family history of cancer had a significantly higher risk of lung cancer (aOR = 1.64; 95% CI = 1.17–2.29; p = 0.004). These findings highlight the need for targeted screening and early detection strategies for high-risk individuals.