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October 5, 2025Neuro-OncologyOpen Access

P14.07.b Car T-Cell Therapy in Primary Central Nervous System Lymphomas: A Multicenter Retrospective Study From the Loc Network

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Authors

FBFrançois BouilleMBMarine BaronRHRoch Houot

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Overview

Retrospective analysis indicates improved complete response rates in PCNSL patients treated with CAR T-cells, suggesting potential for expanded use.

Key Points

  • Complete response achieved in 58% of patients receiving CAR T-cell therapy, indicating significant efficacy.
  • Two-year progression-free survival rate of 44% suggests lasting benefits from CAR T-cell treatment in PCNSL.
  • Cytokine release syndrome occurred in 95% of patients, with most cases being manageable.
  • This large-scale retrospective study highlights the potential of CAR T-cells in a heavily pre-treated population.

Cite This Study

Bouille et al. (2025) studied this question.

synapsesocial.com/papers/68e24e6bd6d66a53c2473b2ehttps://doi.org/10.1093/neuonc/noaf193.468
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CAR T‐cell therapy induces a high rate of prolonged remission in relapsed primary CNS lymphoma: Real‐life results of the LOC network2024 · 66 citations
  2. 2P14.05.B CAR T-CELL THERAPY DOES NOT LEAD TO MEDIUM-TERM NEUROCOGNITIVE DETERIORATION IN PATIENTS WITH CENTRAL NERVOUS SYSTEM LYMPHOMAS. A LOC NETWORK STUDY2025
  3. 3Outcomes of CD-19–directed CAR-T therapy in patients with primary and secondary central nervous system lymphoma: A multi-center observational study.2026
  4. 4Prospective phase I/II study of CD19-directed CAR-t therapy in relapsed/refractory central nervous system lymphoma: Clinical outcomes and safety profile2025 · 1 citations
  5. 5Efficacy and safety of chimeric antigen receptor T-cell therapy in primary central nervous system lymphoma: a systematic review and meta-analysis2026