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This is a Quantitative Study study.

October 5, 2025Open Access

Discovery of rare antigen-specific TCRs via replicate profiling

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The assay captured over 90 SARS-CoV-2-specific TCRβ clonotypes, revealing distinct T cell subsets.
In a cohort of five donors, it identified nearly 1,000 CD4+ and CD8+ TCR clonotypes for various antigens.
The method ensures accurate TCRα/TCRβ pairing using single-cell transcriptomics for enhanced analysis.
This platform supports vaccine and immunotherapy development, linking T cell functions to specific antigens.

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This assay identifies antigen-specific TCRs in PBMC, demonstrating sensitivity to low-frequency clones.

Egorov et al. (2025) studied this question.

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