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October 5, 2025Open Access

A Modular Genetic Code Expansion Approach to Site-Specific Lysine Acylations

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Authors

PKPascal KnechtTNTuan‐Anh NguyenKLKathrin Lang

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Overview

This modular approach allows for diverse lysine acylations in proteins, suggesting new possibilities for studying post-translational modifications.

Key Points

  • The modular strategy successfully installs diverse lysine acylations onto proteins, enhancing tools for biochemical research.
  • This approach utilizes genetic code expansion alongside chemoselective reactions to create a variety of acyl modifications.
  • Probing protein-RNA interactions reveals the role of lysine acylation in regulating enzymatic activity and structure.
  • This method supports systematic studies of lysine acylation, paving the way for further exploration of protein functions.

Cite This Study

Knecht et al. (2025) studied this question.

synapsesocial.com/papers/68e24e6fd6d66a53c2473efehttps://doi.org/10.1101/2025.10.03.680225
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Expanding the Genetic Code with Lysine Aminoacylation2026 · 1 citations
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  4. 4Non-hydrolyzable acetyllysine analogs to study protein acetylation in vitro and in cells2026
  5. 5Repurposing a plant peptide cyclase for targeted lysine acylation2024 · 8 citations