Observational analysis reports the bloomy rind sign in leptomeningeal metastasis, suggesting early diagnostic potential for lung adenocarcinoma.
The bloomy rind sign, which appears as hyperintensities on FLAIR along the surface of the brainstem without gadolinium contrast enhancement, is a rare and early finding indicative of leptomeningeal metastasis in patients with lung adenocarcinoma, often associated with EGFR gene mutations.
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Tao et al. (2025) studied this question.
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