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October 5, 2025Journal of Medical VirologyOpen Access

Novel Mechanism of the L‐Type Voltage‐Gated Channels/Calpains Axis in Influenza A Virus‐Induced Autophagosome Activity

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Authors

HMHannah MurphyHLHinh Ly

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Overview

Observational analysis reveals the l-type voltage-gated channels affect autophagosome activity in A549 cells, suggesting new antiviral strategies.

Key Points

  • IAV infection increases autophagosome accumulation, promoting viral replication in human lung adenocarcinoma A549 cells.
  • The Cav1.3 isoform of l-type voltage-gated channels is crucial for regulating calcium influx and calpain-2 activity.
  • Pharmacologic stimulation of LTCCs restores calcium levels, reducing autophagosome formation and H1N1 IAV replication.
  • Calpain-2 cleaves LC3A, influencing the balance between autophagosome formation and lysosomal fusion, pivotal for viral replication.

Cite This Study

Murphy et al. (2025) studied this question.

synapsesocial.com/papers/68e25378d6d66a53c2474344https://doi.org/10.1002/jmv.70631
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