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October 5, 2025The Professional Medical JournalOpen Access

Preventive effect of dorzolamide- timolol combination on intraocular pressure hikes after intravitreal bevacizumab (Avastin) injection.

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Authors

HMHassam MukhtarMayo HospitalZIZukhruf IjazMayo HospitalAIAmna IqbalDow University of Health Sciences

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Implication

Randomized trial shows dorzolamide-timolol prevents IOP spikes in proliferative diabetic retinopathy, suggesting effective prophylaxis.

Key Points

  • Dorzolamide-timolol significantly reduces post-injection intraocular pressure spikes, showing its potential as a preventive measure.
  • The trial demonstrated a mean intraocular pressure of 9.20 mmHg in the trial group, compared to 15.37 mmHg in controls, indicating a significant difference (p < 0.001).
  • Randomized controlled trial comparing intraocular pressure changes after intravitreal bevacizumab with and without prophylaxis.
  • Routine prophylactic use of dorzolamide-timolol may be beneficial for patients with proliferative diabetic retinopathy to manage intraocular pressure.

Cite This Study

Mukhtar et al. (2025) studied this question.

synapsesocial.com/papers/68e2537cd6d66a53c24744d5https://doi.org/10.29309/tpmj/2025.32.10.9330
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