New synthesis method constructs a tetracyclic core in furanosteroids, suggesting versatile applications.
We developed a new synthetic strategy for furanosteroids and constructed the BE ring system in one step by a Ni-catalyzed reductive cyclization cascade. The subsequent oxidative elaboration led to the efficient formation of a BCDE tetracyclic core embedded in these furanosteroids. Furthermore, a synthesis of the carbon skeleton of nodulisporiviridin C was achieved, as well, through this method.
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Xu et al. (2025) studied this question.
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