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October 5, 2025NeuropsychopharmacologyOpen Access

Early-life neural correlates of behavioral inhibition and anxiety risk

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Authors

CFCourtney A. FilippiAMAlice MasseraJXJiayin Xing

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Overview

This review highlights neural processes associated with behavioral inhibition and anxiety risk in infants, suggesting implications for understanding early development.

Key Points

  • Infants with behavioral inhibition show distinct neural processes related to attention and control.
  • Exposure to maternal anxiety during infancy is linked to changes in stimulus processing and developmental risk.
  • Focusing on early-life neural correlates is crucial for understanding anxiety risk trajectories across development.
  • A longitudinal, multi-modal approach is recommended for studying neurobehavioral profiles related to anxiety risk.

Cite This Study

Filippi et al. (2025) studied this question.

synapsesocial.com/papers/68e28310dcef4a166ce03cachttps://doi.org/10.1038/s41386-025-02235-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of child behavioral inhibition in the intergenerational transmission of anxiety in early childhood2026
  2. 2Brain volumes, behavioral inhibition, and anxiety disorders in children: results from the adolescent brain cognitive development study2024 · 8 citations
  3. 3Social versus non‐social behavioral inhibition: Differential prediction from early childhood of long‐term psychosocial outcomes2023 · 11 citations
  4. 4Rhesus infant nervous temperament predicts peri-adolescent central amygdala metabolism & behavioral inhibition measured by a machine-learning approach2024 · 3 citations
  5. 5Identifiable regional and neural network abnormalities in early childhood anxiety2026