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October 5, 2025Journal of Cosmetic DermatologyOpen Access

Evaluating the Efficacy of Soothing Agents in Mitigating 0.1% Retinol‐Induced Skin Irritation: A Patch Test

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Authors

YYYing YeYFYe FangXCXu Chenlan

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Overview

Randomized, double-blind patch test examined skin irritation from retinol, suggesting effective soothing strategies.

Key Points

  • Retinol-induced skin irritation was effectively mitigated by 2% PLG, showing a low mean cumulative irritation index of 0.26.
  • The study used a randomized double-blind vehicle-controlled design involving 21 healthy participants.
  • 15 soothing agents were tested over five days, grouped based on their efficacy in reducing skin irritation.
  • Results suggest that incorporating skin barrier-repairing ingredients may enhance retinol's applicability for sensitive skin.

Cite This Study

Ye et al. (2025) studied this question.

synapsesocial.com/papers/68e28310dcef4a166ce03cd8https://doi.org/10.1111/jocd.70488
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