Exploration of PD-1 and TIM-3 expression on myeloid cells during immune reconstitution in multiple myeloma, suggesting significant roles.
Background In multiple myeloma (MM), immune checkpoint blockade is being explored as a treatment strategy. However, the role of inhibitory checkpoint receptors on myeloid cells remains poorly understood. The aim of our study was to investigate the expression of PD-1 and TIM-3 on monocytes and monocytic myeloid-derived suppressor cells (M-MDSCs) and their contribution to early immune reconstitution.
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Serpeninova et al. (2025) studied this question.
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