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October 5, 2025Journal of Manipulative and Physiological TherapeuticsOpen Access

Neurophysiological Outcomes of Human Touch and Related Clinical Assessments: A Scoping Review

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Authors

MDManuela DeodatoMMMiriam MartiniATAlessandro Tamma

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Overview

Scoping review outlines pain modulation mechanisms from human touch in healthy volunteers, indicating clinical implications.

Key Points

  • Human touch appears to activate the 'pain matrix', influencing neurophysiological outcomes and pain modulation.
  • The review includes 323 subjects across 1 observational study, 4 clinical trials, and 5 randomized studies.
  • Dynamic touch may offer better pain relief compared to static or non-human touch, suggesting therapeutic potential.
  • Cognitive status of the operator could influence the neurophysiological changes observed in subjects receiving touch.

Cite This Study

Deodato et al. (2025) studied this question.

synapsesocial.com/papers/68e28310dcef4a166ce03d35https://doi.org/10.1016/j.jmpt.2025.08.002
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