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October 5, 2025Stem Cell ReportsOpen Access

Integrated profiling of iPSC-derived motor neurons carrying C9orf72, FUS, TARDBP, or SOD1 mutations

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Authors

GMGuoming MaCXCongcong XiaBLBoyu Lyu

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Overview

Temporal RNA sequencing revealed gene expression changes in motor neurons, highlighting synaptic dysfunction in ALS models.

Key Points

  • Motor neurons with ALS mutations show significant gene expression dysregulation and splicing alterations.
  • Differential expression of RNA-binding proteins in ALS-affected motor neurons may lead to abnormal alternative splicing.
  • Findings support synaptic gene dysfunction as a key feature in familial ALS pathogenesis.
  • Research elucidates shared mechanisms in motor neuron development affected by C9orf72, FUS, TARDBP, or SOD1 mutations.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/68e28310dcef4a166ce03d44https://doi.org/10.1016/j.stemcr.2025.102649
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