Allelic Variant of Cyba Gene (C242) in Acute Myocardial Infarction

Background: The polymorphism of CYBAgene may alter the risk of coronary heart disease. The aim of the present study was aimed to investigate the possible association between C242T (rs4673), a variant of the CYBAgene and its risk of developing CAD. Methods:As a case control study, blood samples from CAD and healthy volunteers were analyzed to determine lipids and lipoproteins level and PCR was done using Helini rs 4673 (C>T) human SNP genotyping PCR kit. Results: The level of cholesterol, triglyceride, LDL and VLDL were increased whereas the level of HDL was decreased in cases when compared to control group. The genotype frequency of cases was CC-0%, CT-42%, TT-58%. Controls: CC-33%, CT22%, TT-10%. Allele frequency in cases are 20 and in controls 54. T allele frequency in cases are 76 and in controls 42. The mean TC value across genotypes, CT is 184.47mg/dl, TT-197 and CC-187.43. The mean TGL value across genotypes, CT is 193.35 mg/dl, TT-210.07 and CC-222.93. The mean HDL value across genotypes, CT is 39.09mg/dl, TT-39.10 and CC-46.75. The mean VLDL value across genotypes, CT is 38.67mg/dl, TT-42.01 and CC-44.58. The mean LDL value across genotypes, CT is 106.70 mg/dl, TT-115.87 and CC-96.10. Conclusion: From the above results conrmed that C242Tpolymorphism of the CYBAgene is a novel genetic marker for CAD subjects.