Key result
CYBA polymorphisms C242T and A640G are associated with up to ~25% lower CAD risk.
Why the study?
Considerable studies investigating the relationship between C242T and A640G polymorphisms of CYBA gene and CAD showed inconsistent results.
Do C242T and A640G polymorphisms in the CYBA gene alter the risk of coronary artery disease?
Meta-Analysis (n=15,700)
Do C242T and A640G polymorphisms in the CYBA gene alter the risk of coronary artery disease?
Odds Ratio: 0.75 (95% CI 0.67–0.84)
The C242T polymorphism in the CYBA gene is associated with a reduced risk of CAD in Asian populations, and the A640G polymorphism is associated with a decreased CAD risk overall.
Supports CAD genetic research; leaves open any role in clinical risk assessment or prevention.
BACKGROUND: Coronary artery disease (CAD) is a leading cause of mortality in many countries. Considerable studies have been carried out to investigate the relationship between the C242T and A640G polymorphisms of CYBA gene and CAD, but the results were still inconsistent. Hence we conducted a meta-analysis to clarify the association. METHODS AND RESULTS: A total of 21 eligible literatures were included in the meta-analysis. We observed a significant decreased risk of CAD for C242T polymorphism in Asian population under an allelic model (OR 0.75; 95% CI 0.67-0.84) and a dominant model (OR 0.69; 95% CI 0.61-0.79), however, in overall population and other population no significant association was revealed. We also found A640G polymorphism may contribute to reducing CAD risk under an allelic model (OR 0.84; 95% CI 0.75-0.93), dominant model (OR0.77; 95% CI 0.64-0.92) and recessive model (OR0.82; 95% CI 0.69-0.97). No publication bias was found. CONCLUSION: Our meta-analysis confirmed a protective effect of C242T polymorphism on CAD in Asian population and indicated that A640G polymorphism was significantly associated with decreased risk of CAD.
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Xu et al. (2014) conducted a meta-analysis in Coronary artery disease (CAD) (n=15,700). C242T and A640G polymorphisms in CYBA gene vs. Wild-type/non-carrier genotypes was evaluated on Risk of coronary artery disease (CAD) (OR 0.75, 95% CI 0.67-0.84). The C242T polymorphism in the CYBA gene was associated with a decreased risk of coronary artery disease in Asian populations (OR 0.75), while the A640G polymorphism reduced CAD risk overall (OR 0.84).
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