A 51-year-old man with severe multifactorial neurocognitive disorders subsequent to delirium, benzodiazepine withdrawal, and preexisting psychiatric illness was referred for 18 F-FDG PET/CT brain imaging in order to rule out an underlying neurodegenerative cause of the symptoms, particularly frontotemporal lobar degeneration. Imaging was impaired by severe motion artifacts, leading to a false-positive result. However, utilizing retrospective data-driven motion correction facilitated a change in diagnosis, ruling out the presence of neurodegenerative disease. The implementation of motion correction of the 18 F-FDG PET dataset proved crucial for the patient, as the exclusion of frontotemporal lobar degeneration formed the basis for continuing psychiatric and psychotherapeutic treatment.
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Maurer et al. (2024) studied this question.
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