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October 3, 2024Analytical Chemistry

Thieno[3,2-b]thiophene for the Construction of Far-Red Molecular Rotor Hemicyanines as High-Affinity DNA Aptamer Fluorogenic Reporters

Ryan E. Johnson Austin Pounder Joshua van der Zalm Aicheng Chen Ian Bell Terence J. Van Raay Stacey D. Wetmore Richard A. Manderville

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Abstract

The construction of far-red fluorescent molecular rotors (FMRs) is an imperative task for developing nucleic acid stains that have superior compatibility with cellular systems and complex matrices. A typical strategy relies on the methine extension of asymmetric cyanines, which unfortunately fails to produce sensitive rotor character. To break free from this paradigm, we have synthesized far-red hemicyanines using a dimethylamino thieno[3,2-

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Cite This Study

Johnson et al. (2024) studied this question.

synapsesocial.com/papers/68e55db1e2b3180350efb366 https://doi.org/10.1021/acs.analchem.4c03151

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