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October 3, 2024Journal of Medicinal ChemistryOpen Access

Addressing the Intracellular Vestibule of the Plasmodial Lactate Transporter PfFNT by p-Substituted Inhibitors Amplifies In Vitro Activity

C Nerlich Finn Tiedjens Robin Hertel Björn Henke Susan Häuer Lea S. Panitzsch Kerrin Hansen Ole Franck Antonio Mete Didier Leroy Dennis Schade Christian Peifer Stefan Hannus Frank Becker Sergio Wittlin Tobias Spielmann Eric Beitz

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Abstract

Inhibition of the lactate transporter PfFNT is a valid novel mode of action against malaria parasites. Current pyridine-substituted pentafluoro-3-hydroxy-pent-2-en-1-ones act as substrate analogs with submicromolar EC

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Nerlich et al. (2024) studied this question.

synapsesocial.com/papers/68e55ee1e2b3180350efbb08 https://doi.org/10.1021/acs.jmedchem.4c01674

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